Lewy bodies hold clues to molecular mechanisms in Parkinson’s

Written by Hannah Wilson

Parkinson's disease is known to affect over 1 million patients in the US alone, its cause its typically unknown and a cure for this progressive disorder has remained elusive. The hallmark sign of Parkinson's disease is the intraneuronal accumulation and progressive spreading of Lewy bodies, formed mainly through the accumulation of alpha-synuclein. Extent of Lewy body clumps and the severity of Parkinson's disease have been well correlated, leading to wide acceptance of the hypothesis that these inclusions accelerate the disease process. Therefore, research to identify and develop molecules capable of decreasing or even halting formation of these alpha-synuclein-containing toxic inclusions...

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